The Tetrahydrofuran Motif in Polyketide Marine Drugs
Laura Fernández-Peña, Carlos Díez‐Poza, Paula González-Andrés, Asunción Barbero
Abstract
Oxygen heterocycles are units that are abundant in a great number of marine natural products. Among them, marine polyketides containing tetrahydrofuran rings have attracted great attention within the scientific community due to their challenging structures and promising biological activities. An overview of the most important marine tetrahydrofuran polyketides, with a focused discussion on their isolation, structure determination, approaches to their total synthesis, and biological studies is provided.
Topics & Concepts
PolyketideTetrahydrofuranMotif (music)Computational biologySpongeChemistryStereochemistryBiologyCombinatorial chemistryOrganic chemistryPhilosophyBiochemistryBotanyGeneBiosynthesisAestheticsSolventSynthetic Organic Chemistry MethodsCarbohydrate Chemistry and SynthesisAsymmetric Synthesis and Catalysis