Building consensus on the application of organoid-based drug sensitivity testing in cancer precision medicine and drug development
Dongxi Xiang, Aina He, Rong Zhou, Yonggang Wang, Xiuying Xiao, Ting Gong, Wenyan Kang, Xiaolin Lin, Xiaochen Wang, Lianxin Liu, Ye‐Guang Chen, Shaorong Gao, Yingbin Liu
Abstract
Patient-derived organoids (PDOs) have emerged as a promising platform for clinical and translational studies. A strong correlation exists between clinical outcomes and the use of PDOs to predict the efficacy of chemotherapy and/or radiotherapy. To standardize interpretation and enhance scientific communication in the field of cancer precision medicine, we revisit the concept of PDO-based drug sensitivity testing (DST). We present an expert consensus-driven approach for medication selection aimed at predicting patient responses. To further standardize PDO-based DST, we propose guidelines for clarification and characterization. Additionally, we identify several major challenges in clinical prediction when utilizing PDOs.