Effect of Paclitaxel Stereochemistry on X-ray-Triggered Release of Paclitaxel from CaWO<sub>4</sub>/Paclitaxel-Coloaded PEG-PLA Nanoparticles
Kaustabh Sarkar, Sandra E. Torregrossa-Allen, Bennett D. Elzey, Sanjeev Narayanan, Márk Langer, Gregory A. Durm, You‐Yeon Won
Abstract
human tumor xenograft study; at short times (<1 month), concurrent PEG-PLA/CWO/PTX-S NPs produced a greater tumor-suppression effect, whereas PEG-PLA/CWO/PTX-B NPs had a longer-lasting radio-sensitizing effect. This study demonstrates the importance of the stereochemistry of a drug in a therapy based on a controlled release formulation.
Topics & Concepts
PaclitaxelPEG ratioChemistryEthylene glycolHomonuclear moleculeNanoparticleNuclear chemistrySolubilityStereochemistryPharmacologyChemotherapyMaterials scienceNanotechnologyOrganic chemistryMedicineSurgeryMoleculeEconomicsFinanceMedical Imaging Techniques and ApplicationsNanoparticle-Based Drug DeliveryManagement of metastatic bone disease