Experimental and theoretical study on spectral features, reactivity, solvation, topoisomerase I inhibition and in vitro cytotoxicity in human HepG2 cells of guadiscine and guadiscidine aporphine alkaloids
Renyer A. Costa, Gabriel de A. Barros, Jonathas N. da Silva, Kélson Mota Teixeira de Oliveira, Daniel P. Bezerra, Milena Botelho Pereira Soares, Emmanoel Vilaça Costa
Topics & Concepts
ChemistrySolvationTopoisomeraseDensity functional theoryHOMO/LUMOComputational chemistryMoleculeNatural bond orbitalCytotoxicityIntermolecular forceStereochemistryDNAIn vitroOrganic chemistryBiochemistrySynthesis and Biological EvaluationCancer therapeutics and mechanismsBioactive Compounds and Antitumor Agents