Variant calling from scRNA-seq data allows the assessment of cellular identity in patient-derived cell lines
Daniele Ramazzotti, Fabrizio Angaroni, Davide Maspero, Gianluca Ascolani, Isabella Castiglioni, Rocco Piazza, Marco Antoniotti, Alex Graudenzi
Abstract
ingle-cell sequencing experiments enable the investigation of cell-to-cell heterogeneity at unprecedented resolution 1 , and this is especially relevant in the study of cancer evolution 2 . In ref. We integrated the analyses
Topics & Concepts
CellComputational biologyTranscriptomeCell cultureBiologyIdentity (music)Basal cellCancer researchGeneticsMedicineGenePathologyGene expressionPhysicsAcousticsSingle-cell and spatial transcriptomicsCancer Genomics and DiagnosticsCell Image Analysis Techniques