Antitumor effects of rhamnazinon sorafenib-treated human hepatocellular carcinoma cell lines via modulation of VEGF signaling and PI3K/NF-κB p38/caspase-3 axes cross talk
Yasmin H. Habiba, Gamal A. Omran, Maged W. Helmy, Maha E. Houssen
Topics & Concepts
SorafenibAngiogenesisDownregulation and upregulationCancer researchPI3K/AKT/mTOR pathwayViability assayKinaseMTT assayMAPK/ERK pathwayCell growthSignal transductionApoptosisVascular endothelial growth factorp38 mitogen-activated protein kinasesChemistryKinase insert domain receptorHepatocellular carcinomaMedicineVascular endothelial growth factor AVEGF receptorsBiochemistryGeneFlavonoids in Medical ResearchMelanoma and MAPK PathwaysPI3K/AKT/mTOR signaling in cancer