Sequential Cross-linking of Gallic Acid-Functionalized GelMA-Based Bioinks with Enhanced Printability for Extrusion-Based 3D Bioprinting
Hatai Jongprasitkul, Sanna Turunen, Vijay Singh Parihar, Minna Kellomäki
Abstract
in GelMA (30% modification) with 10% GA (GelMA30GA-5Fe) provided the optimum printability, shape fidelity, and structural integrity. The dual network inside the printed constructs significantly enhanced the viscoelastic properties. Printed cylinders were evaluated for their printing accuracy. The printed structures of GelMA30GA-5Fe provided high stability in physiological conditions over a month. In addition, the optimized ink also offered good tissue adhesion and antioxidant property. This catechol-based sequential cross-linking method could be adopted for the fabrication of other single-polymer bioinks.
Topics & Concepts
GelatinGallic acidMaterials scienceExtrusionPolymerAdhesionSelf-healing hydrogelsCatecholChemical engineeringPolymer chemistryComposite materialChemistryOrganic chemistryAntioxidantEngineering3D Printing in Biomedical ResearchAdditive Manufacturing and 3D Printing TechnologiesInnovative Microfluidic and Catalytic Techniques Innovation