New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
Matthew L. Arwood, Yao Liu, Shannon Harkins, David M. Weinstock, Lei Yang, Kristen E. Stevenson, Olivia D. Plana, Jingyun Dong, Haley Cirka, Kristen L. Jones, Anniina Virtanen, Dikshat Gopal Gupta, Amanda Ceas, Brian Lawney, Akinori Yoda, Catharine Leahy, Mingfeng Hao, Zhixiang He, Hwan Geun Choi, Yaning Wang, Olli Silvennoinen, Stevan R. Hubbard, Tinghu Zhang, Nathanael S. Gray, Loretta S. Li
Topics & Concepts
MutationCancer researchSmall moleculeKinasePolycythemia veraIn vivoJanus kinase 2ChemistryMedicineBiologyBiochemistryGeneGeneticsImmunologyMyeloproliferative Neoplasms: Diagnosis and TreatmentCytokine Signaling Pathways and InteractionsChronic Myeloid Leukemia Treatments