Visible-Light-Mediated α-Ketoacylations of <i>N</i>H-Sulfoximines with <i>gem</i>-Difluoroalkenes
Yongliang Tu, Peng Shi, Carsten Bolm
Abstract
A photochemical approach for the preparation of α-keto-N-acyl sulfoximines from NH sulfoximines and gem-difluoroalkenes has been developed. In the presence of NBS, the reactions proceed in air without the need of a photocatalyst or additional oxidant. Results of mechanistic studies suggest that the two oxygens in the products stem from water and dioxygen.
Topics & Concepts
ChemistryCombinatorial chemistryPhotocatalysisPhotochemistryMedicinal chemistryOrganic chemistryCatalysisSynthesis and Catalytic ReactionsFluorine in Organic ChemistryRadical Photochemical Reactions