Conformational Dynamics Allows Sampling of an “Active-like” State by Oncogenic K-Ras-GDP
Patrick Grudzien, Hyunbum Jang, Nicholas Leschinsky, Ruth Nussinov, Vadim Gaponenko
Topics & Concepts
GTPaseGTP'MutationChemistrySmall GTPaseMutantSignal transductionGuanosine diphosphateConformational changeMolecular dynamicsCell growthStereochemistryBiochemistryGuanosine triphosphateEnzymeGeneComputational chemistryProtein Kinase Regulation and GTPase SignalingErythrocyte Function and PathophysiologyEnzyme Structure and Function