Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens
Zheng Zheng, Haixiang Liu, Shaodong Zhai, Haoke Zhang, Guo‐Gang Shan, Ryan T. K. Kwok, Chao Ma, Herman H. Y. Sung, Ian D. Williams, Jacky W. Y. Lam, Kam Sing Wong, Xianglong Hu, Ben Zhong Tang
Abstract
Mitochondria-targeted photosensitizers with highly efficient singlet oxygen generation, bright near-infrared AIE and good two-photon absorption are obtained through ingenious molecular engineering for cancer cell-selective photodynamic therapy.
Topics & Concepts
Singlet oxygenPhotodynamic therapyPhotochemistryPhotosensitizerMelanomaTwo-photon excitation microscopyInfraredChemistryAblationOptoelectronicsMaterials scienceFluorescenceOxygenCancer researchOpticsMedicinePhysicsInternal medicineOrganic chemistryNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies