Targeting stromal components in pancreatic ductal adenocarcinoma: a review
Hani Shihadeh, Ahmad Yousef, Ahmad Al-leimon, Hussein Abu-Rumman, Laith Kreshan
Abstract
studies, studies on murine models of PDAC and clinical studies. While targeting some stromal components in PDAC yielded disappointing results in clinical studies, others have shown promise in multiple settings. More research efforts should be directed towards identifying additional stromal targets and evaluating their therapeutic potential. In addition, comprehensive clinical studies are essential to evaluate the safety and effectiveness of agents targeting stromal components of PDA of agents targeting stromal components of PDAC, both as monotherapies and in combination with standard surgical and pharmacological treatments for PDAC to improve patient's outcomes.
Topics & Concepts
MedicineStromal cellPancreatic ductal adenocarcinomaCancer researchPancreatic cancerBioinformaticsPreclinical researchTherapeutic approachTargeted therapyClinical trialClinical PracticePancreatic carcinomaTherapeutic windowOncologyPancreatic and Hepatic Oncology ResearchCancer Research and TreatmentsFerroptosis and cancer prognosis