Improved, gram-scale synthesis of sildenafil in water using arylacetic acid as the acyl source in the pyrazolo[4,3-<i>d</i>]pyrimidin-7-one ring formation
Joydev K. Laha, Upma Gulati, Saima Saima, Anjali Gupta, Harish Kumar Indurthi
Abstract
An improved, gram-scale synthesis of the blockbuster drug sildenafil, used for the treatment of male erectile dysfunction, has been developed.
Topics & Concepts
ChemistryGramSildenafilRing (chemistry)Combinatorial chemistryScale (ratio)Organic chemistryBacteriaInternal medicineQuantum mechanicsPhysicsGeneticsBiologyMedicineSexual function and dysfunction studiesPhenothiazines and Benzothiazines Synthesis and ActivitiesSexuality, Behavior, and Technology