TCR sequencing: applications in immuno-oncology research
Ángel Fernández Sanromán, Kroopa Joshi, Lewis Au, Benny Chain, Samra Turajlic
Abstract
•T-cell receptor (TCR) interaction with major histocompatibility complex-antigen complexes leads to antitumour responses.•TCR sequencing analysis allows characterisation of T cells that recognise tumour neoantigens.•T-cell clonal revival and clonal replacement potentially underpin immunotherapy responses.
Topics & Concepts
T-cell receptorComputational biologyDNA sequencingMedicineOncologyBiologyImmunologyT cellGeneticsDNAImmune systemCancer Immunotherapy and BiomarkersCancer Genomics and DiagnosticsCAR-T cell therapy research