α-Synuclein Locus Triplication Causes Parkinson's Disease
A. B. Singleton, Andrew Singleton, Matthew J. Farrer, Janel Johnson, Andrew Singleton, A. Singleton, Stephen Hague, Jennifer M. Kachergus, Mary Hulihan, Terhi Peuralinna, A. Dutra, Robert Nussbaum, S. Lincoln, Anthony Crawley, M Hanson, Demetrius M. Maraganore, Charles H. Adler, Mark Cookson, Manfred D. Muenter, Maria Fortuna Baptista, David W. Miller, Jan Blancato, John Hardy, Katrina Gwinn
Abstract
Impaired Autophagic-Lysosomal Fusion in Parkinson's Patient Midbrain Neurons Occurs through Loss of ykt6 and Is Rescued by Farnesyltransferase Inhibition,
Topics & Concepts
Parkinson's diseaseLocus (genetics)DiseaseNeuroscienceGeneticsBiologyMedicineInternal medicineGeneParkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatmentsNuclear Receptors and Signaling