Cu(<scp>ii</scp>) and V(<scp>iv</scp>)O complexes with tri- or tetradentate ligands based on (2-hydroxybenzyl)-<scp>l</scp>-alanines reveal promising anticancer therapeutic potential
Nádia Ribeiro, İpek Bulut, Buse Cevatemre, Carlos M. Teixeira, Yasemin Yıldızhan, Vânia André, Pedro Adão, João Costa Pessoa, Ceyda Açılan, Isabel Correia
Abstract
O)] (8) were further evaluated and their mechanism of action was determined to be apoptosis, evidenced by AnnexinV staining and the increase in caspase 3/7 activity. Compounds 3, 7 and 8 also exhibit DNA cleavage activity, involving the formation of reactive oxygen species and were able to induce genomic damage in cells as determined by COMET assay.
Topics & Concepts
ChemistryStereochemistryCombinatorial chemistryMetal complexes synthesis and propertiesMetal-Catalyzed Oxygenation MechanismsVanadium and Halogenation Chemistry