Fighting metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux by mitochondria-targeting AIEgens
Yan Su, Hai Lin, Ying Tu, Mengmeng Wang, Guandong Zhang, Jin Yang, Hong‐Ke Liu, Zhi Su
Abstract
strategy not only promoted cytotoxicity towards cancer cells but also provided a new pathway for the treatment of metallodrug resistance.
Topics & Concepts
AutophagyFlux (metallurgy)ChemistryMetabolismMitochondrionDrugDrug resistanceCell biologyDrug metabolismPharmacologyBiochemistryBiologyApoptosisGeneticsOrganic chemistryAutophagy in Disease and TherapyAdvanced Nanomaterials in CatalysisMetal-Organic Frameworks: Synthesis and Applications