Enabling neighbour labelling: using synthetic biology to explore how cells influence their neighbours
Mattias Malaguti, Tamina Lebek, Guillaume Blin, Sally Lowell
Abstract
Cell-cell interactions are central to development, but exploring how a change in any given cell relates to changes in the neighbour of that cell can be technically challenging. Here, we review recent developments in synthetic biology and image analysis that are helping overcome this problem. We highlight the opportunities presented by these advances and discuss opportunities and limitations in applying them to developmental model systems.
Topics & Concepts
BiologySynthetic biologyComputational biologyDevelopmental biologyLabellingData scienceCognitive scienceCell biologyComputer sciencePsychologyBiochemistryCell Image Analysis Techniques3D Printing in Biomedical ResearchSingle-cell and spatial transcriptomics