The unique effect of TDP-43 on hippocampal subfield morphometry and cognition
Ashley Heywood, Jane Stocks, Julie A. Schneider, Konstantinos Arfanakis, David A. Bennett, Mirza Faisal Beg, Lei Wang
Abstract
• We explored postmortem TDP-43 burden and antemortem hippocampal surface deformation. • TDP-43 was uniquely associated with inward deformation in the hippocampus. • Deformation patterns account for co-existing disease showing TDP-43’s unique effect. • Deformation was significantly correlated with cognition scores.
Topics & Concepts
Hippocampal formationDeformation (meteorology)CognitionHippocampusNeurosciencePsychologyMedicineMaterials scienceComposite materialDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCraniofacial Disorders and Treatments