The Blood−Brain Barrier in Neuroimmune Interactions and Pathological Processes
A. S. Dyatlova, N. S. Novikova, B. G. Yushkov, Е. А. Корнева, В. А. Черешнев
Abstract
The blood-brain barrier (BBB) is a kind of filter, highly selective in relation to various types of substances. The BBB supports the immune status of the brain and is an important regulator of neuroimmune interactions. Some of the molecular and cellular features of the BBB, as well as the five main pathways of neuroimmune communication mediated by the BBB, are analyzed in this article. The functions of the BBB in neuroimmune interactions in various diseases are discussed: multiple sclerosis and Alzheimer's and Parkinson's diseases. The latest data on BBB dysfunction in COVID-19 coronavirus infection caused by the SARS-CoV-2 virus are considered.
Topics & Concepts
Blood–brain barrierNeuroscienceImmune systemMultiple sclerosisNeuroinflammationMedicineCentral nervous systemBiologyImmunologyInflammationNeuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function StudiesVagus Nerve Stimulation Research