Extensive tissue-specific expression variation and novel regulators underlying circadian behavior
Maria Litovchenko, Antonio C.A. Meireles-Filho, Michael Frochaux, R. Bevers, Alessio Prunotto, Ane Martín Anduaga, Brian Hollis, Vincent Gardeux, Virginie Braman, Julie Russeil, Sebastián Kadener, Matteo Dal Peraro, Bart Deplancke
Abstract
mutation that, as shown by protein structural modeling and brain immunohistochemistry, disrupts the light-driven flavin adenine dinucleotide cofactor photoreduction, providing in vivo support for the importance of this conserved photoentrainment mechanism. Together, our study revealed pervasive tissue-specific circadian expression variation with genetic variants acting upon tissue-specific regulatory networks to generate local gene expression oscillations.
Topics & Concepts
Circadian rhythmCircadian clockDrosophila melanogasterTranscriptomeBiologyPopulationComputational biologyVariation (astronomy)Evolutionary biologyCell biologyGeneticsGene expressionNeuroscienceGeneMedicinePhysicsEnvironmental healthAstrophysicsCircadian rhythm and melatoninGenetics, Aging, and Longevity in Model OrganismsSpaceflight effects on biology