Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma
Hua Wu, Yuyuan Chen, Bin Li, Chun Li, Jun Guo, Jia You, Xian Hu, Dong Kuang, Shibo Qi, Liu Pin, Lei Li, Chuanrui Xu
Topics & Concepts
ROCK1ROCK2FasudilMitosisCell growthCell cycleCancer researchMitotic catastropheCell cycle checkpointCell biologyBiologyRho-associated protein kinaseCellChemistryKinaseProtein kinase ABiochemistryProtein Kinase Regulation and GTPase SignalingCell death mechanisms and regulationEndoplasmic Reticulum Stress and Disease