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Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein

Hui‐Yun Hwang, Joong Sup Shim, Dasol Kim, Ho Jeong Kwon

2020Autophagy134 citationsDOIOpen Access PDF

Abstract

; BiFC: biomolecular fluorescence complementation; CAMKK2/CAMKKB: calcium/calmodulin dependent protein kinase kinase 2; CC: compound C; DARTS: drug affinity responsive target stability; HUVECs: human umbilical vein endothelial cells; Inda: indatraline; STK11/LKB1: serine/threonine kinase 11; MAPT: microtubule associated protein tau; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; 3-MA: 3-methyladenine; MEFs: mouse embryonic fibroblasts; MTOR: mechanistic target of rapamycin kinase; PI3K: phosphoinositide 3-kinase; Rapa: rapamycin; Sert: sertraline; RPS6KB1: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; SLC6A4/SERT1: solute carrier family 6 member 4; TFEB: transcription factor EB; VDAC1: voltage dependent anion channel 1; WT: wild-type; WM: wortmannin.

Topics & Concepts

AutophagyVDAC1BiologyCell biologyAMPKProtein kinase AMechanistic target of rapamycinPI3K/AKT/mTOR pathwayTFEBCasein kinase 1AMP-activated protein kinaseKinaseBiochemistrySignal transductionApoptosisEscherichia coliGeneBacterial outer membraneAutophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsCannabis and Cannabinoid Research
Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein | Litcius