Discovery of new 1 <i>H</i> -pyrazolo[3,4- <i>d</i> ]pyrimidine derivatives as anticancer agents targeting EGFR <sup>WT</sup> and EGFR <sup>T790M</sup>
Ahmed A. Abdel Gaber, Mohamed Sobhy, Abdallah Turky, Hanan Gaber Abdulwahab, Ahmed A. Al‐Karmalawy, Mostafa A. Elhendawy, Mohamed. M. Radwan, Eslam B. Elkaeed, Ibrahim M. Ibrahim, Heba S. A. Elzahabi, Ibrahim H. Eissa
Abstract
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Topics & Concepts
PyrimidineChemistryT790MStereochemistryCombinatorial chemistryEpidermal growth factor receptorBiochemistryGefitinibReceptorLung Cancer Treatments and MutationsSynthesis and biological activityPI3K/AKT/mTOR signaling in cancer