SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice
Yu-ran Ren, Yangliang Ye, Ying Feng, Tifei Xu, Yu Shen, Jia Liu, Suling Huang, Jianhua Shen, Ying Leng
Topics & Concepts
GluconeogenesisPhosphoenolpyruvate carboxykinaseAcetylationSIRT2EndocrinologyInternal medicineChemistryNAD+ kinaseAcetyltransferaseGlycolysisBiochemistryGlucose homeostasisHistone acetyltransferaseMetabolismBiologyDiabetes mellitusEnzymeInsulin resistanceSirtuinMedicineGeneSirtuins and Resveratrol in MedicineMetabolism, Diabetes, and CancerBiochemical Acid Research Studies