Base‐Promoted Synthesis of N−H Free Pyrroles <i>via</i> net [3+2]‐Cycloaddition
Huimin Jin, Fan Zhou, Zhenhua Xiang, Lingfeng Chen, Guang Liang, Patrick J. Walsh, Jie Li
Abstract
Abstract A base‐promoted net‐[3+2] cycloaddition of nitriles and 1‐arylpropynes for the synthesis of pyrroles is described. The developed method provides convenient access to various 2,5‐disubstituted or 2,4,5‐trisubstituted pyrroles in 40% to 96% yields (32 examples). Among methods for the synthesis of pyrroles, the protocol presented here stands out for its convenience and atom‐economy.
Topics & Concepts
ChemistryCycloadditionAtom economyBase (topology)Combinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisMathematicsMathematical analysisSynthesis and Characterization of PyrrolesCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods