Palladium-catalyzed three-component carbonylative synthesis of 2-(trifluoromethyl)quinazolin-4(3<i>H</i>)-ones from trifluoroacetimidoyl chlorides and amines
Zhengkai Chen, Le‐Cheng Wang, Jiajun Zhang, Xiao‐Feng Wu
Abstract
An efficient and practical approach for the synthesis of 2-(trifluoromethyl)quinazolin-4(3<italic>H</italic>)-ones through palladium-catalyzed three-component carbonylative reaction has been developed.
Topics & Concepts
ChemistryTrifluoromethylPalladiumCatalysisComponent (thermodynamics)Combinatorial chemistryMedicinal chemistryOrganic chemistryThermodynamicsAlkylPhysicsQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationCatalytic C–H Functionalization Methods