Computer vision as a new paradigm for monitoring of solution and solid phase peptide synthesis
Chunhui Yan, Calum Fyfe, Laura Minty, Henry Barrington, Craig Jamieson, Marc Reid
Abstract
(a measurement of colour contrast), giving comparable isolated peptide yield and purity at 65-95% reduced overall reaction time. The same colour data enabled data-rich monitoring of reaction rate attenuation, consisted with computationally-derived measures of amino acid steric bulk. These findings provide a foundation for exploring the use of camera technology and computer vision towards automated and online mechanistic profiling of SPPS.
Topics & Concepts
Phase (matter)PeptidePeptide synthesisComputer scienceSolid-phase synthesisComputer visionArtificial intelligenceNanotechnologyChemistryMaterials scienceBiochemistryOrganic chemistryChemical Synthesis and AnalysisMachine Learning in BioinformaticsAntimicrobial Peptides and Activities