In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP
Dongwei Kang, Da Feng, Lanlan Jing, Yanying Sun, Fenju Wei, Xiangyi Jiang, Gaochan Wu, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Topics & Concepts
ChemistryClick chemistryIn situTriazoleCombinatorial chemistryHuman immunodeficiency virus (HIV)StereochemistryDrug discoveryEC50Hydrogen bondHydrophobic effectIn vitroMoleculeBiochemistryOrganic chemistryVirologyBiologyHIV/AIDS drug development and treatmentClick Chemistry and ApplicationsHIV Research and Treatment