A <i>S</i>-substituted Nile Blue-derived bifunctional near-infrared fluorescent probe for <i>in vivo</i> carboxylesterase imaging-guided photodynamic therapy of hepatocellular carcinoma
Beilei Wang, Yong Huang, Dezhi Yang, Jiayao Xu, Xiaohong Zhong, Shulin Zhao, Hong Liang
Abstract
and significantly inhibits tumor growth by imaging-guided PDT. Therefore, this study offers a promising and attractive platform for activatable imaging-guided PDT of HCC.
Topics & Concepts
Photodynamic therapyFluorophoreIn vivoFluorescenceMaterials scienceFluorescence-lifetime imaging microscopyPhototoxicityPreclinical imagingHepatocellular carcinomaQuenching (fluorescence)BiophysicsCarboxylesterasePhotochemistryChemistryCancer researchIn vitroMedicineBiochemistryOpticsBiologyPhysicsBiotechnologyEnzymeOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials