Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor
Panupong Mahalapbutr, Vannajan Sanghiran Lee, Thanyada Rungrotmongkol
Abstract
of -17.93 ± 1.49 kcal/mol) was significantly higher than that of the lactitol/TAS1R2 system (-8.53 ± 1.78 kcal/mol), in line with the experimental relative sweetness. These findings provide an in-depth understanding of the differences in the sweetness response between maltitol and lactitol, which could be helpful to design novel polyol derivatives with higher sweet taste perception.
Topics & Concepts
MaltitolSweetnessPolyolChemistryTasteMonomerMolecular dynamicsStereochemistryFood scienceOrganic chemistryComputational chemistrySugarPolymerPolyurethaneBiochemical Analysis and Sensing TechniquesPhotochromic and Fluorescence ChemistryOlfactory and Sensory Function Studies