Recent advances in the potential role of RNA N4-acetylcytidine in cancer progression
Shujun Zhang, Yafeng Liu, Xiao Ma, Xiaohui Gao, Yi Ru, Xinjun Hu, Xinyu Gu
Abstract
Abstract N 4 -acetylcytidine (ac 4 C) is a highly conserved chemical modification widely found in eukaryotic and prokaryotic RNA, such as tRNA, rRNA, and mRNA. This modification is significantly associated with various human diseases, especially cancer, and its formation depends on the catalytic activity of N-acetyltransferase 10 (NAT10), the only known protein that produces ac 4 C. This review discusses the detection techniques and regulatory mechanisms of ac 4 C and summarizes ac 4 C correlation with tumor occurrence, development, prognosis, and drug therapy. It also comments on a new biomarker for early tumor diagnosis and prognosis prediction and a new target for tumor therapy.