Intramolecular chaperone-assisted dual-anchoring activation (ICDA): a suitable preorganization for electrophilic halocyclization
Xihui Yang, Haowei Gao, Jiale Yan, Jia Zhou, Lei Shi
Abstract
In this study, a catalyst-free and highly efficient approach to access seven types of small-sized, medium-sized, and large-sized heterocyclic units via halocyclization was developed, leveraging the use of suitable preorganization by the ICDA model.
Topics & Concepts
ElectrophileIntramolecular forceChemistryCombinatorial chemistryPolyeneReagentRational designCatalysisStereochemistryNanotechnologyOrganic chemistryMaterials scienceCatalytic C–H Functionalization MethodsVanadium and Halogenation ChemistrySynthesis and Catalytic Reactions