Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain
Blue B. Lake, Song Chen, Brandon C. Sos, Jean Fan, Gwendolyn E. Kaeser, Yun C. Yung, Thu Elizabeth Duong, Derek Gao, Jerold Chun, Peter V. Kharchenko, Kun Zhang
Topics & Concepts
BiologyComputational biologyHuman brainEpigeneticsNeuroscienceCell typeChromatinSingle-cell analysisSingle cell sequencingCellTranscriptomeTranscription factorRemyelinationDNAGeneticsGeneGene expressionPhenotypeCentral nervous systemExome sequencingMyelinSingle-cell and spatial transcriptomicsNeuroinflammation and Neurodegeneration MechanismsGene Regulatory Network Analysis