Development of a Stable Peptide-Based PET Tracer for Detecting CD133-Expressing Cancer Cells
Kuan Hu, Xiaohui Ma, Lin Xie, Yiding Zhang, Masayuki Hanyu, Honoka Obata, Lulu Zhang, Kotaro Nagatsu, Hisashi Suzuki, Rui Shi, Weizhi Wang, Ming‐Rong Zhang
Abstract
Cu]CM-2 PET may not only enable the longitudinal tracking of CD133 dynamics in the cancer stem cell niche but also provide a powerful and noninvasive imaging tool to track down CSCs in refractory cancers.
Topics & Concepts
Positron emission tomographyBiodistributionPeptideCancer stem cellMetastasisCancer researchCancerStem cellEx vivoMolecular imagingCancer cellBiomarkerIn vivoChemistryNuclear medicineMedicineBiologyIn vitroCell biologyBiochemistryInternal medicineBiotechnologyCancer Cells and MetastasisChemical Synthesis and AnalysisImmunotherapy and Immune Responses