Carbon Dot Blinking Enables Accurate Molecular Counting at Nanoscale Resolution
Hua He, Lihua Liu, Xiaoliang Chen, Qian Wang, Xiaojuan Wang, Werner M. Nau, Fang Huang
Abstract
. When applied to G-protein coupled receptors on a cell membrane, we discriminated receptor oligomerization and clustering and revealed ligand-regulated receptor distribution patterns. This is the first example of adapting nanoparticle self-blinking for molecular counting, and this demonstrates the power of CDs as SMLM probes to reliably decipher sub-diffraction structures that mediate crucial biological functions.
Topics & Concepts
ChemistryNanoscopic scaleResolution (logic)NanotechnologyMicroscopyMoleculeNanoparticleBiological systemBiophysicsOpticsMaterials sciencePhysicsArtificial intelligenceOrganic chemistryComputer scienceBiologyAdvanced Fluorescence Microscopy TechniquesForce Microscopy Techniques and ApplicationsAdvanced biosensing and bioanalysis techniques