Design, synthesis, and biological evaluations of novel 3-amino-4-ethynyl indazole derivatives as Bcr-Abl kinase inhibitors with potent cellular antileukemic activity
Ashraf K. El‐Damasy, Heewon Jin, Seon Hee Seo, Eun‐Kyoung Bang, Gyochang Keum
Topics & Concepts
ChemistryIndazoleK562 cellsChronic myelogenous leukemiabreakpoint cluster regionDasatinibABLImatinibKinasePotencyIC50LeukemiaImatinib mesylateCancer researchPharmacologyStereochemistryBiochemistryTyrosine kinaseIn vitroMyeloid leukemiaSignal transductionReceptorImmunologyBiologyChronic Myeloid Leukemia TreatmentsEosinophilic Disorders and SyndromesFungal Plant Pathogen Control