Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect Hematopoietic Differentiation
Di Wang, Tao Zhang, Katarina Madunić, Antonius A. de Waard, Constantin Blöchl, Oleg A. Mayboroda, Marieke Griffioen, Robbert M. Spaapen, Christian G. Huber, Guinevere S. M. Lageveen‐Kammeijer, Manfred Wuhrer
Abstract
. In conclusion, we show that GSL glycan expression levels are associated with hematopoietic AML classifications and TF and GT gene expression. Further research is needed to dissect the regulation of GSL expression and its role in hematopoiesis and associated malignancies.
Topics & Concepts
Myeloid leukemiaGlycanGlycomicsBiologyGATA2GlycosphingolipidTranscriptomeGlycosylationHaematopoiesisMyeloidRUNX1Transcription factorCell cultureGlycomeGene expressionCell biologyChemistryMolecular biologyBiochemistryGeneCancer researchStem cellGlycoproteinGeneticsGlycosylation and Glycoproteins ResearchAcute Myeloid Leukemia ResearchUbiquitin and proteasome pathways