Characterization and Evaluation of the Pro-Coagulant and Immunomodulatory Activities of Polysaccharides from <i>Bletilla striata</i>
Wanchen Zhai, Enwei Wei, Rui Li, Tianyi Ji, Yueyao Jiang, Xiaoxiao Wang, Yiying Liu, Zhiying Ding, Hongli Zhou
Abstract
results showed that BSP-1-BSP-4 elicited pro-coagulant capacities by shortening the activating partial thromboplastin time, prothrombin time, and thrombin time and elevating the fibrinogen content. Immunomodulatory activity was evaluated by MTT assay, the pinocytic capacity and NO production. Although BSP fractions did not affect RAW 264.7 cell viability, they, especially BSP-2, enhanced the immunomodulatory activity by increasing the pinocytic capacity and NO production. Overall, BSP may be developed as a potential coagulant with immunomodulatory effects.
Topics & Concepts
PolysaccharideChemistryPartial thromboplastin timeMonosaccharideFood scienceThrombin timeFucoidanBiochemistryImmunologyMedicinePlateletBiological and pharmacological studies of plantsPolysaccharides and Plant Cell WallsNatural Compound Pharmacology Studies