Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels
Hao Shao, Xiaokai Li, Shigenari Hayashi, Jeanette L. Bertron, Daniel M. C. Schwarz, Benjamin C. Tang, Jason E. Gestwicki
Topics & Concepts
BenzothiazoleChemistryHsp70Heat shock proteinChaperone (clinical)Penetrant (biochemical)BiophysicsAllosteric regulationBiochemistryStereochemistryReceptorPathologyGeneOrganic chemistryBiologyMedicineHeat shock proteins researchComputational Drug Discovery MethodsProtein Structure and Dynamics