Highly <i>E</i>-Selective Synthesis of α-Fluoro-β-arylalkenyl Sulfones from <i>gem</i>-Difluoroalkenes with Sodium Sulfinates
Yuxiu Li, Xiangqian Li, Xiaowei Li, Dayong Shi
Abstract
The straightforward synthesis of α-fluoro-β-arylalkenyl sulfones under transition-metal- and base-free conditions has been described, which displays broad functional group compatibility and high stereoselectivity. In particular, the strategy is also applied to the late-stage modification of complex natural products and drugs.
Topics & Concepts
ChemistryStereoselectivityCompatibility (geochemistry)Combinatorial chemistrySodiumTransition metalOrganic chemistryCatalysisChemical engineeringEngineeringFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesCarbohydrate Chemistry and Synthesis