Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds
Mohammad Akbarzadeh, Ilka Deipenwisch, Beate Schoelermann, Axel Pahl, Sonja Sievers, Slava Ziegler, Herbert Waldmann
Topics & Concepts
TubulinMicrotubuleComputational biologySmall moleculeProfiling (computer programming)BiologyDrug discoveryHigh-throughput screeningPhenotypic screeningContext (archaeology)Ligand binding assayPlasma protein bindingPhenotypeBiochemistryChemistryCell biologyGeneReceptorComputer scienceOperating systemPaleontologyCell Image Analysis TechniquesAdvanced Fluorescence Microscopy TechniquesMicrotubule and mitosis dynamics