Endothelin-1 drives invadopodia and interaction with mesothelial cells through ILK
Ilenia Masi, Valentina Caprara, Francesca Spadaro, Lidia Chellini, Rosanna Sestito, Andrea Zancla, Alberto Rainer, Anna Bagnato, Laura Rosanò
Abstract
R antagonist, inhibits the adhesion and spreading of tumor cells to intraperitoneal organs, and invadopodium marker expression. As prognostic factors, high EDNRA/ILK expression correlates with poor SOC clinical outcome. These findings provide a framework for the ET-1R/β-arr1 pathway as an integrator of ILK/Rac3-dependent adhesive and proteolytic signaling to invadopodia, favoring cancer/stroma interactions and metastatic behavior.
Topics & Concepts
InvadopodiaCell biologyPodosomeCancer researchIntravasationExtracellular matrixPAK1ChemistryAdherens junctionMoesinCancer cellIntegrin-linked kinaseRAC1BiologySignal transductionKinaseCancerInternal medicineEzrinCadherinCellMedicineCytoskeletonProtein kinase ABiochemistryCyclin-dependent kinase 2Receptor Mechanisms and SignalingCell Adhesion Molecules ResearchCellular Mechanics and Interactions