Multi-ancestry fine-mapping improves precision to identify causal genes in transcriptome-wide association studies
Zeyun Lu, Shyamalika Gopalan, Yuan Dong, David V. Conti, Bogdan Paşaniuc, Alexander Gusev, Nicholas Mancuso
Topics & Concepts
Expression quantitative trait lociLinkage disequilibriumBiologyGenome-wide association studyGenetic associationComputational biologyPleiotropyIdentification (biology)GeneticsQuantitative trait locusConfoundingAssociation mappingLinkage (software)GeneTranscriptomeEvolutionary biologyHaplotypeSingle-nucleotide polymorphismAlleleGene expressionPhenotypeGenotypeStatisticsMathematicsBotanyGenetic Associations and EpidemiologyPeroxisome Proliferator-Activated ReceptorsBioinformatics and Genomic Networks