Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats
Linglei Kong, Yinzhong Ma, Zhiyuan Wang, Nannan Liu, Guodong Ma, Chengdi Liu, Ruili Shi, Guanhua Du
Topics & Concepts
Tissue plasminogen activatorHMGB1Hypoxia (environmental)TLR4MedicineNeuroinflammationInfiltration (HVAC)Plasminogen activatorPharmacologyInflammationPlasminDownregulation and upregulationCancer researchImmunologyChemistryInternal medicineBiochemistryOrganic chemistryEnzymeGeneOxygenPhysicsThermodynamicsAcute Ischemic Stroke ManagementIntracerebral and Subarachnoid Hemorrhage ResearchNeuroinflammation and Neurodegeneration Mechanisms