Effect of monovalent salt concentration and peptide secondary structure in peptide-micelle binding
Suvankar Ghosh, Gopal Pandit, Swapna Debnath, Sunanda Chatterjee, Priyadarshi Satpati
Abstract
. Increasing NaCl concentration incrementally delayed LL-14:micelle binding by shielding the overall charges of the interacting partners. LL-14 binding to the SDS micelle was significantly faster relative to that of the zwitterionic DPC micelle due to electrostatic reasons. Cationic α-helical amphipathic peptides (with positively charged N-terminus) with low salt-ion concentration seemed to be ideal for faster SDS binding.
Topics & Concepts
MicellePeptideChemistrySalt (chemistry)BiophysicsChromatographyBiochemistryAqueous solutionOrganic chemistryBiologyAntimicrobial Peptides and ActivitiesLipid Membrane Structure and BehaviorRNA Interference and Gene Delivery