Discovery of X10g as a selective PROTAC degrader of Hsp90α protein for treating breast cancer
Qingna Jiang, Minghai Fu, Yuanling Tang, Ge Li, Guihui Tu, Xinhua Wu, Qiurong Wu, Xiuwang Huang, Jianhua Xu, Yang Liu, Lixian Wu, Yang Liu, Lixian Wu
Topics & Concepts
Hsp90Heat shock proteinChemistryProteolysisHsp90 inhibitorGene isoformGeldanamycinCancer researchToxicityMetastasisIn vivoChaperone (clinical)CancerBiochemistryBiologyMedicineInternal medicinePathologyEnzymeGeneOrganic chemistryBiotechnologyUbiquitin and proteasome pathwaysPeptidase Inhibition and AnalysisSignaling Pathways in Disease