The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid
L Donner, Laura Mara Toska, Irena Krüger, Sandra Gröniger, Rubén Barroso, Alice Burleigh, Diego Mezzano, Susanne Pfeiler, Malte Kelm, Norbert Gerdes, Steve P. Watson, Yi Sun, Margitta Elvers
Abstract
Blocking these pathways may therapeutically reduce amyloid plaque formation in cerebral vessels and the brain parenchyma of patients.
Topics & Concepts
GPVIPlateletCerebral amyloid angiopathyChemistryCollagen receptorIntegrinFibrinogenPlatelet activationPlatelet membrane glycoproteinCell biologyReceptorInternal medicineBiochemistryBiologyMedicineDiseaseDementiaAlzheimer's disease research and treatmentsAdvanced Glycation End Products researchBlood properties and coagulation