Tenascin C in pancreatic cancer-associated fibroblasts enhances epithelial mesenchymal transition and is associated with resistance to immune checkpoint inhibitor.
Satoru Furuhashi, Yoshifumi Morita, Akio Matsumoto, Shinya Ida, Ryuta Muraki, Ryo Kitajima, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi
Abstract
-high CAFs play a crucial role in tumor progression and resistance to ICI therapy in PAAD patients, and targeting TNC and its interactions with cancer cells may provide a potential strategy for improving the efficacy of ICI therapy in PAAD.
Topics & Concepts
Epithelial–mesenchymal transitionPancreatic cancerTenascin CCancer researchCancerImmune checkpointTenascinImmune systemTumor microenvironmentStromal cellStromaCancer cellDesmoplasiaMedicineExtracellular matrixBiologyImmunotherapyMetastasisInternal medicineImmunologyImmunohistochemistryFibronectinCell biologyCancer Immunotherapy and BiomarkersCell Adhesion Molecules ResearchCancer Cells and Metastasis