Molecular Imaging of Cardiac Amyloidosis
Ahmad Masri, Syed Bukhari, Yvonne S. Eisele, Prem Soman
Abstract
Transthyretin and light-chain amyloidosis are the 2 main causes of cardiac amyloidosis. Recent developments in molecular imaging have transformed our ability to diagnose transthyretin cardiac amyloidosis noninvasively and unmasked a hitherto unrecognized prevalence of the disease. This review summarizes the current and evolving imaging approaches, their molecular structural basis, and the gaps in imaging capabilities that have arisen as a result of parallel developments in pharmacotherapy delivering the first effective treatment options for this condition.
Topics & Concepts
TransthyretinAmyloidosisCardiac amyloidosisMolecular imagingMedicineAmyloid fibrilAmyloid (mycology)DiseasePathologyBiologyAmyloid βBiotechnologyIn vivoAmyloidosis: Diagnosis, Treatment, OutcomesPeptidase Inhibition and AnalysisSarcoidosis and Beryllium Toxicity Research